Abstract: The change regulation of pH value, Eh value and leaching rate with time during the process of uranium ore acid leaching and bacteria leaching in column was studied, the kinetic characteristic of acid leaching and bacteria leaching was analyzed by JMA dynamics model. The results show that in the acidification stage, the pH value and uranium leaching rate increase, while the Eh value decreases with time in the same series of the acidification system. In the bacterial leaching stage, the pH value, Eh value and uranium leaching rate increase with leaching time in the same series of the leaching system, and with the increase of acidification and bacterial leaching series, the variable quantities of the pH value, Eh value and uranium leaching rate decrease. The dynamics analyses show that acidification dynamics equation is -ln(1-α)=(0.534 9-0.310 3)t^{0.175 7～0.701 6}, the leaching process is controlled by chemical reaction in initial stage and controlled by diffusion in later stage. The bacterial leaching dynamics equation is -ln(1-α)=(0.132 5-0.002 3)t^{0.212 7～2.033 0}, the leaching process is also controlled by the chemical reaction in initial stage and controlled by diffusion in middle stage, and the reaction rate is close to zero in later stage.