Abstract: Nucleate boiling heat transfer plays an important role in the heat and mass transfer. The mechanism and the heat and mass transfer of nucleate boiling are still the focus of the study. With the improvement of experimental methods, the microlayer model was confirmed and received extensive attention. The diffusion interface method was used to track the phase interface. Through the research on the heat and mass transfer in microlayer, the correlation of the microlayer thickness with the heat flux and gasification rate was established. The partial differential equation of the microlayer model was introduced at the bottom of the bubble. The effect of the change of the microlayer on the bubble evolution and the temperature distribution of the heating wall was studied in the condition of nucleate boiling. The results show that the bubble evolution process and the heating wall temperature distribution are in good agreement with those of the experiment, which indicates the accuracy of the model. Furthermore, the variation law of the microlayer, the dry zone and the bottom radius of the bubble and the heating wall temperature distribution were analyzed.