Abstract: With the development of the safety assessment approach of nuclear power plants (NPPs), a risk-informed analysis methodology combining traditional deterministic methodology and probabilistic safety assessment (PSA) has aroused a widespread concern in nuclear safety authorities and nuclear power plant owners. Following the international application of risk-informed analysis methodology, the framework of risk-informed large break loss of coolant accident (LBLOCA) was proposed, and the peak cladding temperature (PCT) margin of CPR1000 nuclear power plant was re-evaluated in this paper. In the PSA analysis, 162 probabilistic sequences were identified and quantified after LBLOCA occured. Then 18 probabilistically significant sequences were selected for the deterministic methodology analysis with deterministic realistic method (DRM). Then the risk-informed PCT margin was evaluated by two different methods, namely the expecting value estimation method and the sequence probability coverage method. The results show that the PCT margin evaluated by the risk-informed LBLOCA is about 36-55 ℃, which is greater than that of the DRM by 16-35 ℃.