Abstract: In order to consider the propagation characteristics of the source in the probabilistic seismic hazard analysis, the method of combining stochastic simulation with probabilistic seismic hazard analysis was proposed, considering the effect of source mechanism, path and site effect, and could get more accurate uniform hazard spectrum (UHS). A method to simulate the historical earthquake in the site-specific of the nuclear power plant (NPP) and develop the UHS with an equal rate of being exceeded was proposed. To compare the NPP seismic performance of different ground motions generated by existing site spectrum (SL-2), the UHS generated by the safety evaluation report and the US RG1.60 spectrum, three-dimensional finite element model was created to dynamic analysis. The results show that the response of different spectra to the structure is quite different. The response of UHS is closer to SL-2 and slightly larger than the SL-2, but UHS is less than US RG1.60 spectrum. The UHS based on stochastic simulation method can provide a reference for the seismic design of NPP.