Abstract: Combining the feature of reactor neutron physics equation and non-structure mesh technology, a method appropriating for structure/non-structure mesh calculation was proposed. Taking the reactor neutron diffusion equation and 1st order discrete ordinate transport equation as an example, the implementation of the method was introduced by demonstrating the region discretization, the equation discretization and the implementation of boundary condition. The code developed using the method calculated the effective multiplication factors of BN-600, CFR1000 and BWR cell. The comparison of calculation results between the code and other codes shows that the method for reactor physics analysis is reasonable.