Abstract: In pressurized water reactors, utilizing dodecylamine (DDA) can reduce the deposition of corrosion significantly in steam generator, and ethanolamine (ETA)+ DDA is a promising water condition in secondary circuit, but DDA might contaminate the condensate polishing resin. Three kinds of resins were chosen to carry out series of pollution experiments under different concentrations of DDA/ETA+DDA at 25, 40 and 55 ℃, and circulation pollution and recover experiments were made under ETA+DDA condition at 25 ℃. The experimental results show that the cation exchange resin is more susceptible to DDA pollution, and with the increase of DDA concentration, the resin pollution is more aggravated. ETA enhances the resin pollution while ETA+DDA condition has synergistic effect on resin pollution. The resin pollution caused by DDA is mainly manifested as the result of resin pore clogging and van der Waals force. It is difficult to regenerate the resin polluted by DDA, and it is eager to develop a new regeneration process. From the resin pollution concentration and the number of anti-pollution point of view, DOWEX MONOSPHERE 650C(H)/MONOSPHERE 550A(OH) resin has better compatibility with DDA, and it can be used as a reference for the selection of condensate polishing resin in nuclear power plant.