Abstract: Pump-induced pressure pulsation is a main factor that caused the fatigue failure of equipments in the nuclear power plants. In this paper, functions for the pump induced pressure pulsation in the heat transfer tubes of the steam generator were derived and the finite element model for all heat transfer tubes with different bending radii was established. Based on these models the dynamic behavior of heat transfer tubes under the pump-induced pressure pulsation was studied. The results show that the frequency and mode of the heat transfer tubes of row 34, 64, 94, 114, 124 and 144 are the most sensitive to the pump-induced pressure pulsation. The maximum stress appears on the heat transfer tube of row 32 under the enveloped pump-induced pressure pulsation, and the rotation frequency of the pump-induced pulsating pressure load has the greatest contribution to the structure response under the pump-induced pressure pulsation. This paper offers a reference for wear analysis of heat transfer tubes in steam generator under pump-induced pressure pulsation.