Abstract: The state of the fluid in a centrifuge cascade is an important factor affecting the cascade separation performance and operation safety. In order to study dynamic cascade hydraulics, a dynamic simulation system for a layer cascade system was established with simulation models for all cascade modules. Some dynamic processes were simulated. The flow equation for the centrifuge light fraction and the dynamic equation for the pressure regulator were determined by comparing the simulation results with the actual operating data. The simulation results obtained by using the improved simulation models demonstrate that the system parameter changes are in good agreement with the actual operation data, and the simulation results are reasonable and reliable, which indicates that the improved simulation models can be applied to the simulation of other centrifuge cascade systems. The obtained parameters can be used as a reference for adjusting and designing practical cascades. Meanwhile, the simulation verification for possible faults in the cascade system was carried out by using the improved system simulation model. The simulation results are in good agreement with the actual operation data.