Abstract: In order to study the centrifugal separation performance of gas mixtures, a method for experimental research was proposed using an easily separable processing gas. C₇F₁₄/SF₆, C₇F₁₄/Xe and CCl₃F/C₂H₄ were chosen as processing gases. A single centrifugal separation experimental system was set up to separate the mixture. The fractional distillation unit was used to obtain the light component gas content in the product/waste flow. Combined with the mass spectrometry results, the basic overall separation factors of the light and heavy components and purification factor of the gas mixture were obtained. The results show this method can conveniently separate light component gases and heavy gases. For centrifugal separation of binary mixtures, it can give the purification factor and the basic overall separation factors of the respective components. This method can be used for the experimental study of the centrifugal separation performance of gas mixtures.