Abstract: Beam screen is one of the key components of high-energy collider. It is used to transfer the heat load caused by synchrotron radiation, image current and electronic cloud in the pipeline, and absorb the gas in the pipeline from the pipeline to the vacuum chamber wall through the pumping hole to ensure the vacuum degree in the pipeline. Under low temperature conditions, the determination of parameters such as the pumping hole area of beam screen and the optimization of vacuum and heat transfer performance of beam screen at different operating temperatures are the key issue in the design of beam screen structure, which is also one of the difficulties in vacuum system design of the new generation particle accelerator. Based on the simulation results of ANSYS, the key parameters of beam screen, such as the pumping hole area, were optimized to improve the pumping capacity of beam screen. In the meantime, the heat transfer performance of beam screen was estimated. Finally, it will provide a good vacuum environment for the operation of super proton-proton collider.