Abstract: The aerosol resuspension behavior was simulated by three-dimensional computational fluid dynamics program GASFLOW. The resuspension rate was calculated by Lagrangian particle model and compared with the results obtained from the calculation of the lumped parameter program ASTEC and the test results obtained from STORM series tests-SR11 in the international standard problems. The results show that GASFLOW program can simulate the aerosol resuspension behavior well. Compared with lumped parameter program, GASFLOW program can clearly and intuitively display the aerosol position distribution at different time, which can provide reference for aerosol behavior analysis under severe accident conditions of pressurized water reactor nuclear power plant.