Abstract: A β-cyclodextrin modified mesoporous silica (SBA-15-CD) material was synthesized by post-grafting using triethoxy (3-isocyanatopropyl)silicon as a crosslinking agent. The effects of solution pH, SBA-15-CD dosage, adsorption time and temperature on the adsorption of U(Ⅵ) on SBA-15-CD were studied by static adsorption test. Scanning electron microscopy (SEM), X-ray powder diffraction (XRD), BET specific surface analysis, Fourier transform infrared spectroscopy (FT-IR) and X-ray photoelectron spectroscopy (XPS) were used to characterize the material and explore the adsorption mechanism of U(Ⅵ) on SBA-15-CD. The experimental results show that when the initial concentration of U(Ⅵ) is 5 mg/L and the temperature is 30 ℃, the optimal conditions for SBA-15-CD to adsorb U(Ⅵ) are: pH=5, 0.20 g/L of SBA-15-CD dosage, and 30 min of time. Under the optimum condition, the equilibrium adsorption amount is 24.4 mg/g, and the U(Ⅵ) removal rate is 98.3%. The adsorption process conforms to the pseudo-second-order kinetic model and the Langmuir isotherm model, that is, the chemical adsorption is the main one, and it is mainly adsorbed by the coordination of hydroxyl, ester and amino groups on the surface with U(Ⅵ). The saturation adsorption capacity of SBA-15-CD reaches 330 mg/g at 30 ℃. Increasing the temperature is favorable for the adsorption, and SBA-15-CD has good reusability.