Abstract: In order to study the influence of different site conditions on the impact response of commercial aircraft impacting on the structure of nuclear power plant, the lumped parameter site dynamic model recommended by the code was used to consider different homogeneous sites. Comparison analysis of impact response of a large commercial aircraft impacting on the steel-plate concrete containment was carried out based on force time-history analysis method. The results show that with the increase of shear wave velocity of site, the impact response of the containment decreases, and when the fixed constraint of bottom nodes of raft foundation is considered, the response is the smallest. When the shear wave velocity of site is large enough (ie. the site is hard enough), the fixed boundary condition is reasonable. When the site is soft, the elastic effect of the site should be considered. The effect of site damping effect on impact response is negligible. For a specific homogeneous site, the impact response of the large commercial aircraft to the steel-plate concrete containment is small, which will not cause the overall damage of the structure, and is acceptable.