Abstract: The sodium-cooled fast reactor container is an integrated pool structure composed of numerous internal components and complex structure. The anisotropy is obvious and the deep penetration problem is serious in the process of neutron transport from core to biological shielding. The calculation of three-dimensional S_N method in large scale is the bottleneck restricting in the design of fast reactor shielding. By combining with high performance computing technology, the parallel computing scheme is used to solve the anisotropic three-dimensional deep penetration shielding calculation in the fast reactor. In this paper, the China Demonstration Fast Reactor (CFR600) reactor block was taken as the research object. Using JSNT-CFR code, the neutron flux rate, photon flux rate, and dose rate in the reactor block were calculated in detail. The calculation results were compared with those of the existing two-dimensional code. The results show that combining the traditional shielding calculation method with high performance computing can meet the requirements of CFR600 reactor block shielding calculation accuracy, and obtain a more comprehensive three-dimensional display effect. It can solve the problem of shielding calculation of complex problems such as complex model and particle penetration depth. It has obvious advantages and provides strong support for the large sodium-cooled fast reactor shielding design.