Abstract: The sequential function specification method (SFSM) was used to quickly invert the near-wall fluid temperature and heat transfer coefficient of two-dimensional pipe. The accuracy of the inverse heat conduction problem was verified by numerical experiment. Meanwhile, the influence of measurement noises on inversion results was discussed. The inversion results show that SFSM can accurately obtain the fluid temperature and convective heat transfer coefficient near the inner wall of pipe. When the measurement noises exist, the inversion value fluctuates in the real value and the amplitude slightly increases with the noises. The average relative error of the estimated fluid temperature near the wall is about 1% with or without measurement noises, while the inversion accuracy of the convective heat transfer coefficient is slightly worse, but the average relative error is less than 20%. It means that the inversion program has a certain anti-noise performance.