Abstract: After a reactor core melt accident, creep failure may occur in the residual solid wall of the reactor pressure vessel (RPV) under the influence of high temperature difference, internal pressure and the weight of the molten pool. In this work, the CPR1000 RPV was used as a research object. The ablation temperature field of the lower head of RPV was solved through the secondary development of the FLUENT software. And then, a CFD-FEM coupling analysis was carried out based on ANSYS Workbench software. The equivalent stress, the equivalent plastic strain and the equivalent creep strain of the RPV within 72 h under severe accident after the wall ablation and temperature field distribution formed stably were calculated. The risk of creep failure of the RPV was evaluated. The results show that when the reactor pit water injection measure puts into operation, the residual solid wall of the RPV will not experience creep failure and plastic deformation failure within 72 h, and besides, the pressure relief can significantly increase the safety margin of the structural integrity of the RPV.