Abstract: Long axial field of view (AFOV) PET is the development direction of future PET. The purpose of this paper is to simulate PET using GATE toolkit to evaluate scatter fraction (SF) and sensitivity for different AFOV and different crystal materials according to NEMA NU2-2012 protocol. The simulation results were compared with the experimental results. The simulation results are in accordance with experimental results, and the reliability of the simulation is verified. As the AFOV increases, the sensitivity also increases, but this increase is non-linear and changes most significantly at a certain length, and the axial length of the most obvious sensitivity change is different for different PET. The crystal with the best sensitivity is LuAP, and the YAP crystal has the lowest sensitivity. The crystal material and AFOV have no significant impact on the scatter fraction.