Abstract: In order to study the thermal-hydraulic characteristics of two-phase flow caused by the special thermal properties of lead/lead-bismuth in lead-based fast reactors, the influence of bubble in fluid channel on the heat transfer capacity and safety of the core was simulated. In this paper the open source CFD calculation software OpenFOAM was adopted, and the numerical simulation was applied based on VOF method to construct a common triangular channel model in lead-based fast reactor. By simulating the two-phase flow of the coolant channel, it is found that as the flow rate increases, the outlet temperature of the coolant decreases. In the flow process of the gas-liquid two-phase flow in the channel, it can be found that the gas phase basically flows inside the channel. In the simulation of the fuel assembly, the corner channel is an area with a large amount of bubbles, which will cause the local heat transfer to deteriorate and cause the fuel assembly to burn out.