Abstract: Photonuclear reaction data are very important for a large range of applications, such as the radiation damage, reactor dosimetry, accelerator shielding, etc. Based on MEND-G program, the photonuclear reaction data of neutrons, protons, ⁴He and other major emergent particles for ^50,51V in the energy range of 0 to 200 MeV were calculated theoretically. The self-consistent analysis of the experimental measurement of photon-induced V isotope nuclear reaction was performed. The photon strength function and the quasi-deuteron model were used to increase the calculation capability of the photonuclear reaction absorption cross section to 200 MeV, providing data basis for the theoretical calculation of photonuclear reactions. After systematic comparison, the theoretical calculations are in good agreement with the experimental measurements, and the data are included in the sub-library of coming CENDL-3.2 for photonuclear data.