Abstract: Operation and control strategy should be designed in accordance with the operational requirements of nuclear power plant. According to the characteristics of the domestic PWR nuclear power plant which is mainly based on base load operation and less demands on load follow operations, the study on design technology of Mode-C operation and control strategy was carried out for the first time. Through the design steps of control strategy design, control rod setting design, nuclear power plant operation mode design, and nuclear power plant operation range design, etc., the design technology of Mode-C operation and control strategy was studied. The design results show that the PWR nuclear power plant with Mode-C mode can choose single variable automatic control mode or dual variable automatic control mode according to the demand of load change. The expected control strategy is achieved. The design technology of Mode-C operation and control strategy in reactor physics is feasible.