Abstract: Altered ilmenite is widely developed in sandstone-type uranium deposits in Mesozoic and Cenozoic sedimentary basins in northern China, which is closely related to U minerals, providing new clues and geological basis for the study on new material and methods for the treatment of U-containing wastewater. In order to provide a material which can be used to treat the U-containing wastewater, sandstone-type U deposit in northern Ordos Basin was selected as an example and the spatial occurrence relationship between altered ilmenite and uranium minerals in hosted-sandstone was studied. On the basis of TiO₂ photocatalytic reduction technology widely used in the environmental field, U enrichment mechanism of altered ilmenite via adsorption and catalytic reduction in sandstone-type U deposits was proposed. Comparative experimental studies confirm that nano-TiO₂ not only has the dual properties of U adsorption and catalytic reduction, but also can superimpose the effects of light and uranium decay energy to achieve catalytic reduction of U-containing wastewater and U resource recovery. Therefore, nano-TiO₂ materials can be used as material for the treatment of U-containing wastewater.