Abstract: After groundwater passes through multi-barrier media and direct contact with the high-level radioactive glass solidified body, radionuclides are released from the solidified body and become the source item for the safety assessment of high-level radioactive waste repository. In order to more accurately predict the long-term disposal behavior of the glass body, the influence of surrounding rock, backfill materials and other factors on the leaching of key elements in the simulated high-level radioactive glass solidified body were investigated. The experimental disposal temperature is 90 ℃, and the simulated high-level radioactive glass solidified body was prepared by a German formula. The results show that the blocking effect of surrounding rocks on different elements in the glass body will be different. The release concentration of B, Re and U elements is the largest among monzonitic granites. When the water content of bentonite is high, the amount of elements released in the glass is large. When the water content of bentonite is low, the amount of elements released in the glass is small. Adding 5% plain glass powder to bentonite can inhibit glass corrosion.