Abstract: Seismic fragility analysis of operating nuclear power plants of China were conducted through seismic fragility analysis methodology based on hybrid data in this paper. Conditional spectra of a nuclear power plant site located in South China were generated by utilizing seismic hazard analysis and deaggregation results. The greedy optimization algorithm was used to select the earthquake records that meet the seismic hazard of the plant site. The analytical data of safety factors FS and FSA of seismic fragility for a nuclear power plant containment of China were obtained through incremental dynamic analysis method. Seismic fragility curves of a nuclear power plant containment of China were generated by utilizing empirical-analytical data, which included analytical data of two above factors and empirical data of other factors. It is suggested that seismic fragility analysis methodology based on empirical-analytical data should be applied to the preliminary seismic fragility analysis of nuclear power plant containment in China.