Abstract: In order to effectively treat the fluorine in wastewater from the uranium conversion production line and reduce its fluorine content to within the emission limit, a treatment process for fluorinecontaining wastewater in a uranium conversion production line combining calcium salt flocculation precipitation method, ultrafiltration and ion exchange method was designed. The main process of the fluorinecontaining wastewater treatment process is to use lime, polyaluminum chloride and polyacrylamide for lime flocculation precipitation to remove most of the fluorine ions, then use ultrafiltration membranes to remove calcium fluoride particles in the wastewater, and finally use special anion exchange resin to selectively adsorb trace fluorine ions to achieve the purpose of further fluorine removal. Through laboratory scale tests and engineering application tests, it is found that this process can reduce the fluorine ion content in fluorinecontaining wastewater to below 2 mg/L, which meets the requirement of less than 10 mg/L in comprehensive discharge standard of wastewater (GB 8978-1996).