Abstract: MOX fuel is one kind of promising and wide use fuel for fast reactor, which have been successfully applied in some fast reactor in the world. Some special properties of pellet and structure materials for MOX fuel assembly are needed to match the very cruel service environment in-pile. Therefore, it is a very big challenge for the design, material and manufacture of the fast reactor MOX fuel. From 90s in 20 century, China Institute of Atomic Energy have led the research and development of MOX fuel for fast rector, collaborated with other companies, and have achieved some important progress in this area. In this paper, a brief introduction of the history, key progress of research and development, and future program of development and application of MOX fuel was given.