Abstract: Event sequences that would lead to an early radioactive release or a large radioactive release are required to be practically eliminated in HAF102—2016. But there are lack of specific acceptance criteria and demonstration method of practical elimination in China. Safety requirement of practical elimination was studied, and some insights, acceptance criteria and demonstration method of practical elimination were proposed in this paper. Demonstration of practical elimination for HPR1000 was evaluated. The main conclusions are as follows: 1) Practical elimination is a higher requirement for the safety design of nuclear power plants. It is not a requirement that accident conditions have no release, but the plant states that could lead to an early or a large radioactive release have been practically eliminated. And conditions that have not been practically eliminated should be fully considered in the design to ensure its radiological consequences limited. 2) With reference to international practice and the relevant requirements of emergency plans and preparations in China, it is the first time to propose the deterministic and probability acceptance criteria for practical elimination in China at this stage. The radiological release acceptance criteria at this stage are suggested that there is no evacuate action beyond 3 km from the site boundary, and no sheltering action beyond 5 km. It is recommended that the DEC B design requirement is less than 100 TBq equivalent 137Cs. This criterion is also the criterion for large radioactive release in the level 2 PSA. 3) Demonstration method of practical elimination was proposed in this paper, and demonstration of practical elimination for HPR1000 was evaluated. In the final analysis, DBA is effectively mitigated by defence in depth, and severe accident prevention and mitigation measures are considered sufficiently for HPR1000. Even if severe accident considered in design is happened, the containment could be intact. Practical elimination is realized on HPR1000.