Abstract: Lead-cooled fast reactor (LFR) is known as a typical reliable new type reactor by the US Department of Energy (DOE), and the potential accidents of LFR are necessary to assess. Steam generator tube rupture (SGTR) accident can cause high-pressure hyperbaric steam-water jetting into liquid lead bismuth eutectic (LBE) pool, and leads to a rapid pressure rising in the reactor primary system together with a potential pressure wave crashing the structures. This paper focuses on the computational fluid dynamics (CFD) analyses of SGTR experimental research on the LIFUS5/MOD2 experiment facility. A two-dimensional symmetrical slice with 1 million 570 thousand structured mesh was established for the experimental reaction vessel, and each side except the injection nozzle were set as adiabatic no slip boundary in order to achieve the non-decompression process. In the aspect of multiphase model settings, the Eulerian-Eulerian two-phase flow model was adopted to track the steam-LBE interface in the transient simulation, and the CSF surface tension polynomial together with Lee substituted evaporation model were considered. In addition, the injection of high-pressure water in each time step was separated to two parts: latent heat and injected steam, so as to calculate both endothermic and jet of flash evaporation simultaneously. Among them, the latent heat was realized by user-defined functions (UDF), and the injected steam was adopted as compressible real gas with R-K gas state equation. Based on the above settings, three established thermal-hydraulics phenomena including pressure rising of LBE environment together with pressure wave spreading, level fluctuation of liquid environment with argon entrainment and level rising of liquid environment and diffusion of injected steam were analyzed. From the results a conclusion can be reached that CFD numerical simulation has little error on calculating pressure rising with pressure wave spreading. In addition, the peak value of pressure wave rises with back pressure of water increasing, and the pressure of partial steam cavity is lower than that of LBE pool around it, in turn inhibits the occurrence of its explosion. Meanwhile, LBE in the middle firstly washes up and impacts the structures, and then entrains the argon when it falls back, in turn causes the combination of argon and steam cavity, or the secondary segmentation to small argon bubbles. Moreover, the diffusion of the steam cavity along the radial direction becomes more intense with the increase of the axial height, accompanies by the steam cavity divided from the center to the edge along the radius.