Abstract: LiF-BeF2-ZrF4-UF4 and LiF-BeF2 have been employed as fuel salt and coolant in liquid fueled molten salt reactor, respectively. A heat exchanger containing both fuel salt and cooling salt is placed inside the reactor vessel to dissipate the heat produced by the reactor. A molten salttoair heat exchanger outside the reactor vessel is used to cool the molten salt, and a molten salt pump is used to drive the circulation of the entire circuit of coolant system. As of the molten salt, LiF-BeF2 coolant, flows through the molten salt heat exchanger located inside the reactor vessel, nuclides in the coolant are activated by 19F(n, α)16N, 19F(n, γ)20F, and 19F(n, p)19O reactions with neutrons in the reactor core, and thus radionuclides such as 16N, 20F and 19O are produced. These radionuclides have radiation impact on the surrounding environment and equipment if they enter the rooms where equipment for molten salt coolant circuit locate. According to the flow process and distribution law of the cooling salt, theoretical calculation formulas to calculate the amount of radionuclide were given. Using theoretical formulas, calculated radioactivities of the three most important radionuclides 16N, 20F and 19O per unit volume of cooling salt are 9.05×106, 8.33×106 and 2.69×105 Bq/cm3 at the outlet of the molten salt heat exchanger, while the radioactivities of the three radionuclides at the same location calculated by ORIGENS program are 8.98×106, 8.58×106 and 2.76×105 Bq/cm3, respectively. The results calculated by the formulas are in good agreement with the data of the ORIGENS program, and the maximum relative deviation between the results of the two methods is 2.92%, indicating that applying the derived formulas to carry out cooling salt activation analysis is reasonable and feasible. These radionuclides, 16N, 20F and 19O, produced in the cooling salt of molten salt reactor release highenergy gamma rays as they decay. The total gamma emissivities of the cooling salt in equipment and pipelines located in the cooling salt storage tank room, in the molten salt-to-air heat exchanger room and in the cooling salt pump room are 8.71×1011, 9.51×1011 and 1.93×1012 s-1, respectively, and the most radioactive area is in the cooling salt pump room. The maximum absorbed dose rate at the location of the cooling salt auxiliary equipment is 45.7 mGy/h without shielding, which cannot meet the requirement of the radiation dose, and which should be less than 50 Gy for the entire life of the equipment (300 full power days). By setting a 30 cm thick concrete shielding wall between the cooling salt auxiliary equipment and the cooling salt pump, the absorbed dose rate at the location of the auxiliary equipment can be reduced to less than 7 mGy/h, thereby the radiation protection requirements for the cooling salt auxiliary equipment can be met.