Abstract: In the field of radiotherapy, dose measurement technology based on the scintillator can realize 3D real-time dose verification. Due to the factors of plasticity and tissue equivalent, liquid scintillation and plastic scintillation restrict the development of this technology. In order to develop a new type of scintillation gel material for radiotherapy dose measurement, the initial gel was prepared based on emulsion polymerization. Combined with Monte Carlo simulation and experimental measurement, inorganic salts were added to the initial gel formulation to optimize the tissue equivalent performance for gamma. The PPO and Bis-MSB contents in the initial formulation were changed by the experimental method to enhance the luminous efficiency of the gel. The results show that after adding 1.0% of ZnCl₂, the relative deviation of gamma tissue equivalent value and ICRU recommended value is less than 5% under each energy segment. When the content of PPO and Bis-MSB is 0.33% and 0.005 6%, the luminous efficiency of gel reaches about 80% of Ultra Gold AB liquid scintillation. After the radiotherapy platform test, the luminous intensity of the scintillation gel material shows a linear response to the dose, which can meet the radiotherapy dose measurement requirements.