Abstract: In order to study the multi-source information 3D fusion modeling technology of in-situ leaching mining area and verify its application effect, C16-1 and C16-2 mining areas of a sandstone type uranium deposit in Xinjiang was taken as the research object. Based on the borehole logging data, a 3D digital model of in-situ leaching area was established by using the implicit modeling based on radial basis function interpolation and Kriging interpolation. Through the joint analysis of the spatial distribution of borehole lithology, thickness proportion and uranium grade distribution, combined with the fluid particle migration study of the model, the main reason for the poor leaching effect of C16-1 compared with C16-2 mining area is found out. The upper ore body of C16-1 mining area can not be effectively leached under the existing drilling engineering and filter layout conditions. Under the guidance of the model, supplementary drilling was carried out in the section with poor leaching effect in C16-1 mining area. The uranium concentration of leaching solution in supplementary drilling is 1.6-7.7 times of the average uranium concentration in C16-1 mining area. It is indicated that this model is a good guidance for in-situ leaching production.