Abstract: The effective performance of target materials within neutron generators is pivotal in determining neutron yield and ensuring system stability. This research investigates the adverse effects that arise from the formation of intermetallic alloys between titanium films and bases in deuterium titanium targets, a prevalent issue that causes substantial degradation in target performance. Aiming to address and counter this challenge, the study introduced an innovative gold-plated technique. The gold-plated was meticulously applied to serve as a barrier between the hydrogen storage layer and the base material of the target. This method was executed to intercept the diffusive processes that could lead to deleterious alloying between the titanium film and the base. The successful application of this technique is paramount in maintaining the integrity and concentration of titanium elements within the coating and, crucially, in protecting the active deuterium nuclei that are essential for effective neutron generation. The investigation proceeded with rigorous comparative analyses conducted under specific beam conditions to evaluate the efficacy of the molybdenum base gold-plated deuterium titanium targets against other materials. The findings are clear and significant and the molybdenum base gold-plated deuterium titanium target demonstrates a superior neutron output with a yield of 1.61×10⁹ s⁻¹, outstandingly surpassing that of both the copper base gold-plated and pure molybdenum base deuterium titanium targets. The integrity of these results was further consolidated through meticulous electron microscope spectral analysis. This analysis confirms the enriched presence of titanium in the molybdenum base gold-plated deuterium titanium target, which helps explain the observed increase in neutron yield. Moreover, detailed computational simulations were employed to discern any possible influence of temperature on deuterium retention within the target. The simulation leads to the exclusion of temperature rise as a contributory factor for deuterium loss, affirming the resilience of the target design against heat-related performance issues. In summary, this seminal piece of research provides vital insights into the intricacies of neutron generation, particularly highlighting the impact of target material selection and surface integrity. Through careful experimentation and analysis, the study advocates the use of a molybdenum base gold-plated for deuterium titanium targets as an effective strategy for ensuring high neutron yields and stable generator operation. The conclusions drawn from this work lay a robust groundwork for the optimization of neutron generator targets, potentially revolutionizing practices within the field. Future applications of this research are expected to extend not only to the improvement of current neutron generator designs but also to the innovation of new systems where maximum neutron yield and stability are crucial. This comprehensive inquiry, therefore, transcends conventional understanding and presents a transformational approach to material engineering in neutron generation, setting a precedent for excellence and efficiency that will undoubtedly guide future advancements in the domain.