Abstract: With the increase of spent fuel burnup, the lanthanide and actinide elements in high-level radioactive waste liquid increase. This article focuses on the influence of praseodymium oxide, which has a high content in high-level radioactive waste liquid of spent fuel burnup, on the structure and properties of high sodium borosilicate glass. The research results show that when the waste capacity is 10wt.% and the amount of praseodymium oxide added is 10wt.%, the glass sample can still maintain a uniform amorphous glass structure. The Raman analysis results show that with the addition of praseodymium oxide, the peak near 1 065 cm⁻¹ tends to shift to the left, and the glass structure Q³ exhibits decreasing trend. The nuclear magnetic resonance analysis results show that with the increase of waste addition and the addition of praseodymium oxide, Q⁴ and Q³ show a trend of firstly decreasing and then increasing, while Q² and Q¹ show a trend of firstly increasing and then decreasing, indicating that the increase in the addition of waste and praseodymium oxide causes the aggregation degree of the glass network structure to firstly decrease and then increase. The chemical stability test results show that under the condition of a waste loading of 0wt.%, the leaching rate of the element increases with the addition of praseodymium oxide. Under the condition of a waste loading of 10wt.%, the leaching rate decreases with the addition of praseodymium oxide, suggestting as the waste loading increases, the glass network structure tends to aggregate and stabilize with the praseodymium oxide addition.