胡子仪, 邱睿, 陈宜正, 胡安康, 武祯, 张辉, 李君利. 重离子相对生物效应的双尺度模拟方法比较研究[J]. 原子能科学技术, 2024, 58(4): 896-902. DOI: 10.7538/yzk.2023.youxian.0363
引用本文: 胡子仪, 邱睿, 陈宜正, 胡安康, 武祯, 张辉, 李君利. 重离子相对生物效应的双尺度模拟方法比较研究[J]. 原子能科学技术, 2024, 58(4): 896-902. DOI: 10.7538/yzk.2023.youxian.0363
HU Ziyi, QIU Rui, CHEN Yizheng, HU Ankang, WU Zhen, ZHANG Hui, LI Junli. Macro- and Micro-scale Dose Simulation of Heavy Ion Relative Biological Effectiveness[J]. Atomic Energy Science and Technology, 2024, 58(4): 896-902. DOI: 10.7538/yzk.2023.youxian.0363
Citation: HU Ziyi, QIU Rui, CHEN Yizheng, HU Ankang, WU Zhen, ZHANG Hui, LI Junli. Macro- and Micro-scale Dose Simulation of Heavy Ion Relative Biological Effectiveness[J]. Atomic Energy Science and Technology, 2024, 58(4): 896-902. DOI: 10.7538/yzk.2023.youxian.0363

重离子相对生物效应的双尺度模拟方法比较研究

Macro- and Micro-scale Dose Simulation of Heavy Ion Relative Biological Effectiveness

  • 摘要: 重离子放射治疗是一种重要的癌症治疗手段,准确评估重离子的辐射生物效应对于提高粒子放疗的精细化水平具有重要意义。本研究基于双尺度剂量学方法和蒙特卡罗模拟,从宏观和微观两个尺度对12C离子的相对生物效应(RBE)进行对比分析。本研究采用宏观的细胞存活线性平方模型(LQ)和微观的微剂量动力学模型(MKM)计算两个尺度的12C离子RBE在体内的分布。蒙特卡罗模拟290MeV/u的展宽12C离子束在水模型内的宏观剂量及传能线密度(LET)分布,进而计算宏观12C离子RBE。同时统计不同位置处体素内的粒子谱信息,并作为二次源项进行微剂量线能谱的模拟,进而计算微观尺度的12C离子RBE。结果显示,10%细胞存活分数对应的物理剂量水平下,坪区两个尺度12C离子RBE计算结果差异为16%,在布拉格峰处差异为25%。本研究提出了一种计算相同照射情况下宏观和微观两种尺度重离子RBE的模拟方法,并为重离子RBE模型的改进和临床应用提供参考。

     

    Abstract: Heavy ion therapy is an important cancer treatment. Accurate evaluation of the biophysical effects of heavy ions is of great significance to improve the refinement level of particle radiotherapy. An aim of this study is to calculate multi-scale relative biological effectiveness (RBE) of heavy ion. Based on multi-scale dosimetry and Monte Carto dose simulation, the RBE of carbon ions were calculated at the macro- and micro-scales, and the results were compared and analyzed to evaluate the biological effects of carbon ions comprehensively. In this study, different dose-effect models of carbon ions were used at the two scales: LQ model was used at macro-scale and microdosimetric kinetics model (MKM) was used at the micro-scale. The Monte Carlo simulation used a water phantom to calculate the macro-scale carbon ion RBE by counting the dose distribution and linear energy transfer (LET), and the information of the particles passing through the voxels was recorded as a secondary source. Micro-dose simulation was carried out with the secondary source to calculate the micro-scale carbon ion RBE. The results show that the RBE calculated at different scales in the plateau region differs by 16%, and the RBE at the Bragg peak differs by 25%. The results of this study presents a method for calculating heavy ion RBE at macro- and micro-scales under the same irradiation situation, and will provide references for the improvement and clinical application of different methods.

     

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